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Because these mechanisms reinforce one another, the overall metabolic effect can appear robust even if any single component varies, which is another reason a clean, isolated read on the gastric-emptying contribution is so hard to obtain from combination-drug outcome data

Start with lower doses to assess tolerance

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Although the gastrointestinal upset can be uncomfortable or even painful when taking GLP-1 drugs like Ozempic and Wegovy, most people adapt within a few weeks

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