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Nevertheless, it has also been demonstrated that glucose deficiency, activation of the system Xc system, high expression of SLC7A11, elevated NADP+/NADPH ratio, extensive NADPH consumption, cystine accumulation, and decreased GSH levels collectively drive ferroptosis [97]
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The conventional adenoma-carcinoma pathway occurs after a genomic event triggered by adenomatous polyposis coli mutation, followed by P53 loss of function or KRAS activation, whereas the serrated tumour pathway is characterised by a CpG island methylation phenotype
Gentle movement supports motility