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Further investigation showed that CPs first reduce the level of skin oxidation, inhibit the expression of the key transcription factor AP-1 (c-Jun and c-Fos), then activate the TGF-/Smad signaling pathway to promote collagen synthesis, inhibit the expression of MMP-1/3 to inhibit collagen degradation, and inhibit skin inflammation to alleviate skin aging in mice
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GHK was also shown to combat copper-dependent oxidation of low-density lipoproteins, while various other common antioxidants, such as superoxide dismutase, only provided protection against oxidation up to 20%
PMCID: PMC8619776
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