fda compounding semaglutide crackdown november 2025 What Patients Need to Know About the GLP-1 Policy Changes FDA proposes a new GLP-1

For instance, the UKs National Institute for Health and Care Excellence (NICE) advises that the GLP-1RA semaglutide be used for up to two years for weight loss

On GLP-1 medications, you're fighting three dehydration mechanisms simultaneously: Reduced thirst signaling (central appetite suppression affects thirst centers) Reduced fluid intake with meals (nausea makes drinking unpleasant) Ongoing fluid loss from glycogen metabolism during weight loss The result is chronic mild dehydration in a substantial portion of patients during titration

2026 Apr 1;142(4):640-649

While complete adverse event data from most TRIUMPH trials is still pending full publication, early reported data aligns with Phase 2 observations

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A cautious, individualised approach to resumption, guided by clinical assessment, minimises these risks and supports optimal surgical recovery