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This is typical for commonly prescribed brand-name medications

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Moreover, patients losing 20-30% of their body weight also contributes to blood pressure lowering effects as well and going back to the earlier graph with 2 out of 3 patients not even being in the obese BMI category, suggests a large number of patients were probably able to reduce dose or stop their blood pressure medicine entirely but since they only had the data for a couple weeks we have to wait for confirmation on that

The execution is where things get tricky