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For quantitative synthesis, effect estimates were collected when available, including HRs, 95% CI, and associated p-values

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Your healthcare provider will have to inform Cigna that you have performed behavioral modifications (e.g., increasing exercise) and a reduced-calorie diet for at least three months, and have either: A BMI of 30 or higher, or A BMI of 27 or higher, plus a weight-related comorbidity approved by Cigna, such as hypertension, Type 2 diabetes, dyslipidemia (high cholesterol), obstructive sleep apnea, or cardiovascular disease Wegovy is also FDA approved for cardiovascular risk reduction

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In certain scenarios, using drugs like metformin or antidepressants off-label is literally the standard of care