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Mechanistic studies of TYRs catalytic activity in CuAAC reaction To further decipher the catalytic performance of TYR, the ab initio molecular dynamics (AIMD) was applied to investigate the geometric and electronic properties of TYR and its catalytic effect on the reaction between the azido group and ethynyl group 27,28
That question eventually led to X39
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12 Combinatorial approaches involving DDR inhibitors, epigenetic modulators, metabolic disruptors and immunotherapeutics hold promise for overcoming resistance and achieving durable clinical responses across malignancies
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