new glp 1 gip drug In a recent study published in Nature, researchers discovered a five-target called lanifibranor that outperforms GLP-1/GIP therapy in obese diabetic mice. This single-molecule compound activates incretin receptor-expressing cells and PPARα/γ/δ Few people still don't realize

N., Keller, M

Glucagon-like peptide-1 receptor activation in the ventral tegmental area decreases the reinforcing efficacy of cocaine

Nicolau J, Nadal A, Sanchs P, Pujol A, Masmiquel L, Nadal C

Glutathione is one of our first lines of defense, a ubiquitous molecule, that is, present throughout our organism, but it is particularly concentrated at the liver level , where it protects the liver cells from toxic molecules: in this case, Glutathione "binds" to the toxic metabolites, neutralizing them

Western blotting showed that TGF-1 + IL-1 treatment time-dependently upregulated the expression of NLRP3, ASC and active caspase-1 p20 in fibroblasts, while GSDMD-NT did not change significantly (Fig

4.4 Augmented renal protective mechanisms GLP_1 receptor agonists provide comprehensive kidney protection via many direct and indirect mechanisms, in addition to glycemic regulation