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For individuals with osteoarthritis, the priority may instead be reducing pain, improving mobility, and maintaining independence in daily life
First, tirzepatide is a dual agonist (targeting both GLP-1 and GIP receptors) and has proven results for weight loss and glycemic control
Novo Nordisk developed semaglutide first as Ozempic for diabetes (2017), then conducted weight loss trials at higher doses and launched Wegovy (2021) specifically for obesity treatment
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Moreover, PAS* has immune signaling capacity and induced cytokines IL-1, IL-6, IL-8, IL-10 and TNF- production in human peripheral blood mononuclear cells (PBMCs) [48]
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