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Neuropeptides 94 , 102250 (2022)

Depending on the trial, the target dose may be 4mg, 9mg or 12mg once weekly

Furthermore, recent studies have demonstrated that GLP-1RAs may exert their anorexigenic effects not only by acting on ARC POMC neurons but also in other brain regions, such as the dorsomedial hypothalamus (DMH) and the dorsal vagal complex in the hindbrain [8, 9]

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GLP-1 Receptor Agonists in the Treatment of Type 2 Diabetes: Role and Clinical Experience to Date

This is normal because it's been shown that people regain up to 2/3 of their body weight once they get off the drug