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Beyond its pancreatic effects, GIP receptors are found in adipose tissue and the brain, where they are believed to play a role in regulating fat metabolism, energy storage, and energy expenditure
Patients with slower hepatic metabolism might retain tirzepatide slightly longer, while those with more robust kidney function might eliminate it somewhat faster, creating minor differences in how long the medication remains clinically effective
Overall treatment discontinuation rates were similar across the retatrutide and placebo treatment arms