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Importantly, PepT1 expression is upregulated during inflammatory bowel disease, making KPV particularly effective in inflamed gut tissue

Author contributions Conceptualization, JZ, SJ, and HL

, 2011, 47 , 5013 (DOI: 10.1039/c1cc10204d) 7 P Sanphui et al , Cryst

Importantly, preclinical studies demonstrated that the synergistic effect of GIPRAs and GLP-1RAs on body weight requires the GABAergic (GABA refers to gamma-aminobutyric acid) GIPR-expressing neurons in the CNS [21, 28]