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doi: 10.1201/9781003022879 87 LazzarottoF.TeixeiraF

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Mechanistically, NNMT suppression increased adipose SAM and NAD, upregulated polyamine flux enzymes (ODC, SSAT), and altered histone methylation consistent with a shift toward oxidative metabolism [2]

Additional work explores its role in muscle recovery, where it may help reduce exercise induced damage and oxidative stress

Here is a straight, evidence-based answer, so you can decide whether B12 shots make sense for you