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In the SURPASS clinical trial program evaluating tirzepatide for type 2 diabetes and the SURMOUNT trials for weight management, insomnia was not identified as a statistically significant adverse event compared to placebo groups, based on published trial results
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Indeed, GLP-1RA therapy appears to be well tolerated overall, and proportions of clinical trial participants discontinuing treatment because of adverse events tend to be low (5.49.9%) [10, 37, 39, 43, 46, 47]
Liver antioxidative stress The antioxidative capacity of the liver tissue is illustrated in Fig
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