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Ribeiro FF, Neves-Tom R, Assaife-Lopes N et al (2016) Axonal elongation and dendritic branching is enhanced by adenosine A2A receptors activation in cerebral cortical neurons

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However, a larger trial in de novo patients without dopaminergic therapy (NCT02655315) found that DFP at 15 mg/kg twice daily for 36 weeks significantly worsened motor symptoms, with Movement Disorder Society-Unified Parkinsons Disease Rating Scale (MDS-UPDRS) scores increasing more in the DFP group compared to placebo (DFP: +15.6 vs