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Extended Data Table 2) produces more interactions with the lipids, possibly further stabilizing the open conformation of TM6, ECL3 and TM7
It targets both the GLP-1 receptor and the GIP receptor
Supportive Therapies To maximize AOD-9604s metabolic benefits, consider integrating: Structured nutrition protocols: Moderate caloric deficit (15-20% below maintenance), adequate protein intake (0.8-1.2 g/lb body weight) to preserve lean mass, strategic carbohydrate timing around training, and whole-food focused diet to support overall metabolic health
High-fiber foods such as legumes, whole grains, vegetables, nuts, and seeds naturally boost GLP-1 production through bacterial fermentation in the colon
However, rare and serious complications can occur, such as acute pancreatitis (indicated by severe, persistent stomach pain that radiates to your back)
If you have Medicare insurance covering it as a diabetes treatment, Ozempic can cost much less
