Chronic alcohol intake can deplete glutathione stores, making supplementation potentially beneficial, but acute alcohol consumption may alter the metabolism of glutathione and affect its efficacy
Alzahrani TF et al
In addition, specific inhibition of TKTL1 mRNA has been shown to inhibit cancer cell proliferation in functional studies
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Campbell A, Heydarian R, Ochoa C, Dwivedi AK, Nahleh ZA
Among other issues are differences in capacity and affinity for the oxidizing substrate, a potential role of thiol peroxidases in H 2 O 2 perception and, as mentioned above, the importance of other peroxidases in H 2 O 2 -dependent substrate oxidations or ROS generation