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The FDA-approved prescribing information for semaglutide does not list hepatotoxicity as a recognized adverse effect, and large-scale clinical trials have not demonstrated an increased risk of liver injury compared to placebo or other diabetes medications
Generally, surrogate endpoints are expected to predict clinical benefits
After 2Y of treatment, liver volumes in most patients were 1.25 multiples of normal (mean reductions: 30% in ASCEND, 49% in ASCEND-Peds, 30% reduction in Phase 1b with 44% reduction after 6.5Y) and mean HDL cholesterol had increased 65% in ASCEND, 137% in ASCEND-Peds, and 115% in Phase 1b (171% increase at 6.5Y)
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