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Anaphylaxis following a B12 injection has been documented in medical literature, particularly in patients with a sensitivity to cobalt or cobalamin compounds
SAM, SAH, and Methylation-Balance Considerations NNMT uses SAM as a methyl donor and generates SAH, so NNMT activity is directly connected to the balance between methyl-donor availability and methylation-product accumulation
Long-term follow-up studies are needed to assess durability of therapeutic effects and to identify any delayed adverse effects or complications that might not be apparent in shorter-term investigations
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