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These are mediated by 11-hydroxylase (P450c11 or CYP11B1), which generates cortisol (followed by activities of the ER enzymes P450c21 and P450c17), and aldosterone synthase (P450c11AS or CYP11B2) which produces aldosterone 91,92,93,94

The addition of the glucagon receptor absent from all other approved or late-stage metabolic peptides activates energy expenditure pathways that the GLP-1 and GIP receptors alone do not reach

PLoS One 10 (7), e0129743

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