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In SUSTAIN 3, SUSTAIN 7 and SUSTAIN 10, the GLP-1RAs semaglutide reduced HbA1c by up to 1.8%, achieved the glycemic control target of HbA1c in 80% of the intervention group, and reduced BW by up to 6.5 kg, outcomes which were superior to liraglutide, exenatide and dulaglutide [28-30]
Excluding Shapiro (2025) yielded a pooled log RR of 0.287 (95% CI: 0.0180.557)
Three reasons: (1) reported lifespan extension and reduced spontaneous tumour incidence in chronically treated rodents
Takeaway: Always apply skincare products from thinnest to thickest consistency
The culture was incubated at this temperature with shaking for an additional 20 h
The effect is from reduced melanin production and lower oxidative stress
