Issues generally arise only when one or both nutrients are consumed in excessive amounts for prolonged periods
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Researchers have been unable to identify a minimum toxic dose, and have reported no teratogenic, genotoxic, anaphylactic, or local toxic effects
Without enough B12, red blood cells can become large and irregular (megaloblastic anemia), which reduces their ability to carry oxygen efficiently
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2 Materials and methods 2.1 Protocol and registration This systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement (Supplementary Table S1