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10.1016/j.cell.2014.02.055 C

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Interestingly, the reversal of TAG levels was more pronounced with post-treatment, suggesting that discontinuation of statin-induced suppression, combined with mitochondrial support, allows for a more robust recovery of lipoprotein metabolism

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Most strikingly, IC 50 values to lower cholesterol accumulation in NPC1 mutant cells for three of the four compounds ( 3 , 6 , 10 ) were in the mid-nanomolar to low-micromolar range