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For both sample clustering and gene clustering, we applied spearman distance as similarity measure between every pair of objects in the dataset, then we generated binary hierarchical cluster tree using linkage function which employs average method for computing the distance between clusters

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Novo Nordisk developed CagriSema as the successor to their blockbuster semaglutide therapy, recognizing that even 2.4 mg of standalone semaglutide left room for improvement

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it occurs in approximately 1 out every 700800 live births [60]