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For Hashimoto patients, weight management is often particularly challenging because hypothyroidism slows metabolism and promotes fluid retention
This delayed effect suggests that long-term metabolic remodeling (and possibly dietary changes following weight loss) may be required to observe microbiome changes in humans
Moreover, patients with acromegaly treated with either GH-receptor antagonists or somatostatin analogues represent a peculiar setting that need to be studied in depth to define safety and efficacy of both drug classes and their interaction with the GH/IGF-1 axis
A pill expands treatment options for patients who may not want to use an injectable, according to the manufacturer and a weight loss doctor
Two GLP-1R agonists have been approved in the United States to treat obesity: semaglutide and LIR, both of which are injected subcutaneously
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