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The 93% amino acid identity between human and rat orthologs suggested that CYP51A1 functions as a highly conserved housekeeping enzyme essential for survival [13, 14]

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In the multiple-dose trial, subjects were originally allocated to four cohorts in a semi-parallel design: healthy subjects receiving oral semaglutide maintenance doses of 20, 40 or 60 mg, and subjects with T2D receiving a maintenance dose of 60 mg