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Novo Nordisk A/S supplied Saxenda (liraglutide) and placebo pens, and Cambridge Weight Plan supplied low-calorie meal replacement products
So these medications have a certain efficacy and effectiveness, and they produce a certain amount of weight loss in an individual, and then that weight loss stops, and that's completely normal
Current evidence suggests they are mostly neutral
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Individuals carrying specific FTO or MC4R variants may experience sharper metabolic shifts that can trigger temporary anxiety as their bodies adapt to improved glucose control and appetite suppression
However, there is limited experience in patients with severe hepatic impairment, and these medications should be used with caution in such cases, preferably with specialist input
