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Across the SURPASS phase 3 programme versus placebo and active comparators, including semaglutide, tirzepatide has shown superior dose-dependent reductions in HbA1c levels up to 2.5% and body weight up to 13%, compared with all comparators [88-91]
Similarly, the periodic retrospective review of sensor data by healthcare providers may prompt changes in treatment, such as adding or removing a medication
Require supplemental rebates from pharmaceutical manufacturers participating in the Medicaid Drug Rebate Program
Black Box Warning GLP-1 receptor agonists, including semaglutide, are contraindicated in individuals with a personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN2)
While a few reports exist, they are not enough to show a clear pattern or risk for most people
Conclusion: Main Points on GLP-1 Dose Titration Getting the dosing right for GLP-1 medications is key to achieving weight loss goals while keeping side effects in check
