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Although the levels of demethylation during the pre-implantation period are significant, a portion of DNA methylation will be kept during the reprogramming after fertilization, including the imprinted genes, which represent an inheritance from the paternal environment to the offspring phenotype (Jiang et al., 2018)
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In db/db mice and HG-exposed HK-2 cells, overexpression of mitofusin 2 restores mitochondrial function, suppresses mitochondrial oxidative phosphorylation, reduces tubular apoptosis and eventually alleviates diabetic kidney injury, and the reverse tendency is observed in mitofusin 2 short hairpin RNA treated db/db mice (82)
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Diacylglycerol-evoked activation of PKC and PKD isoforms in regulation of glucose and lipid metabolism: a review