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doi: 10.3389/froh.2025.1569940 Received 02 February 2025 Accepted 08 April 2025 Published 25 April 2025 Volume 6 - 2025 Edited by Praveen Hoogar, The Apollo University, India Reviewed by Saurabh Kumar, Manipal Academy of Higher Education, India Ashwini Shivakumar, JSS Dental College and Hospital, India Tribikram Debata, SCB Dental College and Hospital, India Updates Copyright 2025 Maitra, Behera, Bose, Chatterjee and Bandyopadhyay

The healing slowdown that accompanies aging relates partly to declining growth hormone levels, reduced blood flow, and less efficient inflammatory responses

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FOXO4-DRI at 25 mM concentration selectively induced p53 nuclear exclusion and apoptosis in the senescent Leydig cells, confirmed by Annexin V-FITC/PI apoptosis assays and immunofluorescent staining of Ser15-phospho-p53 foci

HUBERMAN: Many of the peptide vendors that are out there and physicians that are working with peptides will combine different growth hormone promoting peptides