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Medical weight loss with Semaglutide and Tirzepatide works through several mechanisms: Appetite regulation: These medications mimic a hormone called GLP-1 (glucagon-like peptide-1), which helps control appetite

For many people, food has been a primary source of comfort, stress relief, or dopamine hits for years

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It will be interesting to see how much these medications seem to help with arthritis pain based on weight loss alone versus via other mechanisms