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Since dopamine is critically involved in movement initiation and facilitation through its actions on both direct and indirect pathways in the basal ganglia circuitry [45,46,47], it is plausible to presume that a higher extracellular dopamine level should equate behavioral alterations such as an elevated level of voluntary movements

However, several factors suggest oral BPC-157 may retain meaningful activity

Shimamoto A, Rappeneau V, Munjal H, Farris T, Davis C, Wilson A, Edwards M, Moore C, Reynolds C, Meshul CK

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Therefore, AdoMet supplementation may not alter GSH status in rodents who already have innate compensatory mechanisms for overcoming methionine dysfunction [86]

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