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At 1 mg its occupancy sits near 1%, and liver fat still fell 51% over 48 weeks in the trial participants who started with fatty liver. Natural glucagon reaches a similar 0.5 to 5% engagement during a fast, so 1% is not an unusually small signal

B12 supplements contain only cobalamin, typically in doses from 50 to 1,000+ micrograms, used for confirmed or suspected B12 deficiency

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I started back to work in Aug on a part time basis to get used to sitting long hours again and went full time in Oct