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Many early peptide programs relied on acute or high-dose administration, which produced adverse effects unrelated to therapeutic exposure levels

Assessments of serum GLP-1 took place in 1.5- to 3-h intervals, focusing on the response to breakfast intake (3.8 MJ)

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11.7 Practical Takeaway Framework During GLP-1 therapy: Prioritise protein intake Increase micronutrient density per calorie Monitor symptoms Test selectively when risk factors are present Avoid automatic or excessive supplementation Reassess after significant weight milestones Weight loss should be metabolically effective and nutritionally sufficient

Shughrue, P