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Risk of Type 2 Diabetes: Insulin resistance is a major precursor to the development of type 2 diabetes

Doubling doses is not recommended

Endogenous GLP-1 is rapidly degraded primarily by dipeptidyl peptidase-4 (DPP-4), as well as neutral endopeptidase 24.11 (NEP 24.11) and renal clearance, resulting in a half-life of approximately 2 minutes

Semaglutide is substantially superior to exenatide in weight loss efficacy (14.9% vs 2-4%), glycemic control (SUSTAIN 3 head-to-head), cardiovascular outcomes (proven superiority vs non-inferiority only), and dosing convenience (pre-filled weekly pen vs reconstitution)

For example, alcohol metabolites can promote enzyme synthesis and activate proteases, leading to local autodigestion of pancreatic tissue

The primary outcome (the first occurrence of death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke) was less frequent in the liraglutide group (13.0% vs