Common Side Effects (Both Oral and Injectable): Gastrointestinal Issues: These are the most common side effects for all GLP-1 medications: Nausea: Oral semaglutide (Rybelsus): 11-20% of patients Injectable semaglutide (Wegovy): 44% of patients Injectable tirzepatide (Zepbound): 30-37% of patients Why the difference: Lower bioavailability of oral medication means less systemic exposure, potentially resulting in fewer GI side effects
But there are case reports suggesting that GLP-1 receptor agonists may actually stabilise mast cells in some people, with some clinicians working in this space reporting positive responses in patients with ME/CFS, fibromyalgia, and long COVID who have a significant mast cell component
Metabolites 10 , 186 (2020)
The primary outcome was the percentage of time spent in the target glucose range of 3.910.0 mmol l 1 during the last 4 weeks of each intervention
Adverse reactions Reactions to drugs encompass a broad range of responses to medications, including drug allergy rashes
Use our calorie and nutrition guide for semaglutide to put this in context with your overall dietary plan