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In acetaminophen (APAP)-induced liver injury, CHAC1 indirectly promotes ferroptosis by modulating the ferroptosis suppressor ARF6

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During phase 1 trials in NASH patients, efocipegtrutide showed a half-life of around 5.9 days, and was capable of reducing body weight by 5.1% when administered weekly at 0.08mg/kg, after 12 weeks [36]

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Those experiencing gastrointestinal side effects may benefit from oral rehydration solutions or electrolyte-containing beverages