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Melanotan II is a synthetic cyclic 7-amino-acid lactam analog of -melanocyte-stimulating hormone (-MSH), N-acetylated and C-terminally amidated, with a ring closed by an Asp-to-Lys lactam bridge

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Although pro-oxidant profile was evident in both brain areas, differences in the magnitude of some alterations and in aconitase activity suggested that the functional consequences of oxidative stress may vary across brain regions

Mechanistically, the binding of BPC157 to FBXO22 induces steric hindrance that suppresses FBXO22-mediated ubiquitination and degradation of its substrate BACH1