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doi:10.1086/321262 Reynolds EH

Melatonin synthesis was evaluated by measuring urinary 6-sulfatoxymelatonin, the primary metabolite of melatonin, which increased 1.6-fold in the Epitalon group relative to placebo

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BT from the intestine has been proposed by numerous authors in order to explain sepsis and endotoxemia observed in patients with severe trauma, burns, intestinal obstruction, pancreatitis, and acute liver diseases [4, 58]

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