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Press release on TRANSCEND-T2D-1

Nauck MA, Quast DR, Wefers J, Meier JJ (2021) GLP-1 receptor agonists in the treatment of type 2 diabetes - state-of-the-art

Temporal requirements of insulin/IGF-1 signaling for proteotoxicity protection [PMID: 20003171] Laboratory literature summary: Temporal requirements of insulin/IGF-1 signaling for proteotoxicity protection

This is a retatrutide-specific signal tied to glucagon-receptor activity

Given that most patients on the medication are under 50, the need for exercise and preserving muscle mass is essential to avoid becoming prone to injuries

Exendin-4, but not dipeptidyl peptidase IV inhibition, increases small intestinal mass in GK rats