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DOSAGE Cagrilintide is being developed as a pharmaceutical product in a pre-filled pen device for once-weekly subcutaneous injection
What makes this formula special
Retatrutide, with triple-target effects (it works at the two receptors mentioned above and the glucagon receptor), caused people to lose about a quarter of their body weight after a year in a Phase II study (Jastreboff AM et al, N Engl J Med 2023;389(6):514526), although a follow-up study found the weight loss more in line with tirzepatide
Cathepsin B-responsive linker Cathepsin B is a lysosomal protease that is over-expressed in various cancer cells and involved in numerous oncogenic processes in humans (Gondi and Rao, 2013)
Whelan, K
Verhagen, M
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