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Diet-induced obese (DIO) mice and rats fed a high-fat diet received semaglutide, administered subchronically, and the effects on food intake and BW were evaluated
"Data Extraction and Outcomes" were used to calculate NNT, which yielded either numbers needed to benefit (NNTB) and number needed to harm (NNTH) based on formulas recommended by the Cochrane guidelines [34]
Differential expression ratio and log 2 FC were calculated for each significant gene
3cf and Extended Data Fig
Tirzepatide at its highest dose reaches approximately 22.5% over 72 weeks
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