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Side-effects range from mild (nausea, injection-site discomfort) to serious and even life-threatening (allergic reactions, liver injury, systemic inflammatory response, endotoxin-related events)

In Ireland, the $800 million Kinsale facility deploying a first-of-its-kind hybrid continuous manufacturing platform for complex peptides was formally unveiled in September 2024, already producing tirzepatide, alongside a $2 billion total investment in the Limerick biologics site for biologic active ingredient production

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Oxidative stress can also affect skin health due to the deterioration of the anti-oxidative mechanisms and the increased production of reactive oxygen species (ROS), causing DNA damage and oxidation of the cellular membranes

10.1146/annurev.physiol.64.082201.154705