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Focusing on building and preserving muscle can help protect your long-term progress and avoid the rebound effect often seen after discontinuing medication

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The study points to several anti-inflammatory effects that matter in MCAS: * Reduced activation of inflammatory pathways like TNF- and NF-B * Suppression of the NLRP3 inflammasome (a key driver of chronic inflammation) * Calming of mast-cell-driven immune overactivity In simpler terms: these medications may help mast cells chill out

Tahrani, A

Why it matters: Gradual dosing is the best way to minimize common GI side effects (like nausea and constipation) and improve your chances of staying on the treatment long enough to see life-changing benefits

People have different metabolism and weight