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While enhanced alcohol metabolism may seem protective, elevated CYP2E1 accelerates ethanol oxidation, resulting in higher acetaldehyde production and excessive reactive oxygen species (ROS) generation, including hydroxyethyl radicals, superoxide anions, and hydroxyl radicals [27, 28]

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Mustafa et al.[55] demonstrated that ergosterol peroxide, a compound in shiitake mushrooms, reduces fatty acid accumulation and inhibits the expression of enzymes associated with the synthesis and distribution of unsaturated fatty acids

(Huang et al., 2020) used an ultra-low-input RNA sequencing method (SMART-seq v.4 technology) to investigate the effects of two SSRIs (fluoxetine and paroxetine) on zebrafish larvae