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The combined GLP-1/GIP profile is what gives tirzepatide its edge over semaglutide
This is important, as it means these people may need less medication to achieve the same blood levels of active ingredient as healthy people ( 23 )
Research has also examined its role in upregulating matrix metalloproteinase (MMP) activity alongside their inhibitors (TIMPs), suggesting a finely balanced role in extracellular matrix remodelling rather than simple collagen deposition
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Research protocols typically involve daily subcutaneous injections of 100-300 mcg, usually administered before bedtime to support healthy sleep architecture and stress modulation
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