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Rapid weight reduction induced by GLP-1based therapies has been associated with proportional losses in fat-free mass in adult populations, raising concerns regarding potential impacts on skeletal muscle accrual during adolescencea developmental period characterized by dynamic changes in body composition and linear growth

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et al.) predicts a poor response to GLP-1 agonists precisely because the resistance lies downstream of both receptor classes

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Interestingly, in a study published in 2024, researchers examined the dynamic, wide-ranging molecular environment in the intact human ileum and found that when plant-based foods with intact cellular structures are consumed, they can increase the delivery of nutrients to the ileum, which subsequently can lead to an increased release of satiety peptides (in particular, PYY)

thus, parametric tests were used