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Tandon et al., 2022) the authors evaluated the quality of the clinical trial included in the qualitative synthesis, based on 5 items assessing the randomization process, blinding, and the dropout rate (i.e., the patients lost to follow-up)

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+ Microneedling: Begin use 2448 hours after the procedure, once skin has sealed

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In particular, gastrointestinal disturbance, an expected side effect of these medications, was comparable among combined therapy and placebo groups