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Recognized adverse effects include cholelithiasis, gastrointestinal disturbances, and reductions in lean mass [10,11,12]
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The first licensed agent, talimogene laherparepvec (T-VEC), administered intratumorally, replicates within tumours to lyse infected cells while expressing granulocyte-macrophage colony-stimulating factor (GM-CSF) to prime systemic immunity
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