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Subsequently, 5-HTP undergoes decarboxylation, facilitated by pyridoxal phosphate and the enzyme 5-hydroxytryptophan decarboxylase, yielding serotonin

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This is more likely with higher or sustained doses and is usually reversible once therapy is discontinued

Lower doses of ketamine, on the other hand, have been used in models of chronic pain which highlight the role of PKC in modulating the adaptive response of the organism to nociception

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